Comparative Studies of Palmatine with Metformin and Glimepiride on the Modulation of Insulin Dependent Signaling Pathway In Vitro, In Vivo & Ex Vivo

• Main Authors: Okechukwu Patrick Nwabueze (Author), Mridula Sharma (Author), Abbirami Balachandran (Author), Anand Gaurav (Author), Anis Najwa Abdul Rani (Author), Jeleń Małgorzata (Author), Morak-Młodawska Beata (Author), Charlie A. Lavilla (Author), Merell P. Billacura (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

(1) Insulin resistance, a symptom of type 2 diabetes mellitus (T2DM), is caused by the inactivation of the insulin signaling pathway, which includes IRS-PI3K-IRS-1-PKC-AKT2 and GLUT4. Metformin (biguanide) and glimepiride (sulfonylurea) are both drugs that are derivatives of urea, and they are widel...