Engineering of Saposin C Protein Chimeras for Enhanced Cytotoxicity and Optimized Liposome Binding Capability

• Autores principales: Suzanne I. Sandin (Autor), David M. Gravano (Autor), Christopher J. Randolph (Autor), Meenakshi Sharma (Autor), Eva de Alba (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2021-04-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Saposin C (sapC) is a lysosomal, peripheral-membrane protein displaying liposome fusogenic capabilities. Proteoliposomes of sapC and phosphatidylserine have been shown to be toxic for cancer cells and are currently on clinical trial to treat glioblastoma. As proof-of-concept, we show two strategies...