Lefamulin dosing optimization using population pharmacokinetic and pharmacokinetic/pharmacodynamic assessment in Chinese patients with community-acquired bacterial pneumonia

• Main Authors: Xingchen Bian (Author), Nanyang Li (Author), Yi Li (Author), Xu Zhu (Author), Jicheng Yu (Author), Yingying Hu (Author), Haijing Yang (Author), Qiong Wei (Author), Xiaojie Wu (Author), Jingjing Wang (Author), Guoying Cao (Author), Jufang Wu (Author), Yang Wang (Author), Jing Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PurposeLefamulin is the first pleuromutilin antibiotic approved for the treatment of community-acquired bacterial pneumonia (CABP). However, the pharmacokinetic/pharmacodynamic (PK/PD) characteristics in Chinese CABP patients are not fully understood. This study aimed to evaluate its microbiological...