Cover Image

Lefamulin dosing optimization using population pharmacokinetic and pharmacokinetic/pharmacodynamic assessment in Chinese patients with community-acquired bacterial pneumonia

PurposeLefamulin is the first pleuromutilin antibiotic approved for the treatment of community-acquired bacterial pneumonia (CABP). However, the pharmacokinetic/pharmacodynamic (PK/PD) characteristics in Chinese CABP patients are not fully understood. This study aimed to evaluate its microbiological...

Full description

Saved in:

Bibliographic Details
Main Authors:	Xingchen Bian (Author), Nanyang Li (Author), Yi Li (Author), Xu Zhu (Author), Jicheng Yu (Author), Yingying Hu (Author), Haijing Yang (Author), Qiong Wei (Author), Xiaojie Wu (Author), Jingjing Wang (Author), Guoying Cao (Author), Jufang Wu (Author), Yang Wang (Author), Jing Zhang (Author)
Format:	Book
Published:	Frontiers Media S.A., 2024-10-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Pharmacokinetic, Pharmacokinetic/Pharmacodynamic, and Safety Investigations of Lefamulin in Healthy Chinese Subjects
by: Yingying Hu, et al.
Published: (2023)

Pharmacokinetics, Safety and Pharmacokinetics/Pharmacodynamics Analysis of Omadacycline in Chinese Healthy Subjects
by: Haijing Yang, et al.
Published: (2022)

LZM008, a proposed tocilizumab biosimilar: Pharmacokinetics, safety, and immunogenicity profiles compared with ACTEMRA® in Chinese healthy male subjects
by: Guoying Cao, et al.
Published: (2023)

Pharmacokinetics and safety of mavacamten in healthy Chinese participants with different CYP2C19 phenotypes
by: Xiaojie Wu, et al.
Published: (2024)

Integrative population pharmacokinetic/pharmacodynamic analysis of nemonoxacin capsule in Chinese patients with community-acquired pneumonia
by: Yuancheng Chen, et al.
Published: (2023)

Pharmacokinetics and Safety of Doripenem in Healthy Chinese Subjects and Monte Carlo Dosing Simulations
by: Yu Wang, et al.
Published: (2022)

Safety, tolerability, pharmacokinetics, and immunogenicity of an anti-SARS-CoV-2 monoclonal antibody HFB30132A after single dose intravenous administration in healthy Chinese subjects: a phase 1, randomized, double-blind, placebo-controlled study
by: Shanshan Li, et al.
Published: (2023)

Pharmacokinetics and Pharmacodynamics of Colistin Methanesulfonate in Healthy Chinese Subjects after Multi-Dose Regimen
by: Yaxin Fan, et al.
Published: (2022)

In vitro pharmacokinetics/pharmacodynamics of FL058 (a novel beta-lactamase inhibitor) combined with meropenem against carbapenemase-producing Enterobacterales
by: Zhiwei Huang, et al.
Published: (2024)

Age-Related Differences in Vancomycin-Associated Nephrotoxicity and Efficacy in Methicillin-Resistant <i>Staphylococcus aureus</i> Infection: A Comparative Study between Elderly and Adult Patients
by: Lin Xi, et al.
Published: (2024)

Pharmacokinetics and Pharmacodynamics of Nemonoxacin in a Neutropenic Murine Lung Infection Model Against Streptococcus Pneumoniae
by: Xin Li, et al.
Published: (2021)

Pharmacokinetic/Pharmacodynamic Based Breakpoints of Polymyxin B for Bloodstream Infections Caused by Multidrug-Resistant Gram-Negative Pathogens
by: Xingchen Bian, et al.
Published: (2022)

Dose adjustment not required for contezolid in patients with moderate hepatic impairment based on pharmacokinetic/pharmacodynamic analysis
by: Junzhen Wu, et al.
Published: (2023)

Release and Demand of Public Health Information in Social Media During the Outbreak of COVID-19 in China
by: Songjia Tang, et al.
Published: (2022)

Combined PK/PD Index May Be a More Appropriate PK/PD Index for Cefoperazone/Sulbactam against <i>Acinetobacter baumannii</i> in Patients with Hospital-Acquired Pneumonia
by: Yingjie Zhou, et al.
Published: (2022)

A Phase I, Randomized, Single-Dose Study to Evaluate the Biosimilarity of HOT-3010 to Adalimumab Among Healthy Chinese Male Subjects
by: Hong Zhang, et al.
Published: (2021)

Stress and coping styles among nursing students during the initial period of the clinical practicum: A cross-section study
by: Jing Liu, et al.
Published: (2022)

Construction of an HCC recurrence model basedon the investigation of immune-relatedlncRNAs and related mechanisms
by: Xiang-Xu Wang, et al.
Published: (2021)

The dilemma of antibiotic susceptibility and clinical decision-making in a multi-drug-resistant Pseudomonas aeruginosa bloodstream infection
by: Long Chen, et al.
Published: (2023)

Different Doses of Pharmacological Treatments for Mild to Moderate Alzheimer's Disease: A Bayesian Network Meta-Analysis
by: Tingting Zhang, et al.
Published: (2020)

Research on the development trend, evolution, and spatial local characteristics of the intelligent smart medical industry in the Yangtze River Economic Belt
by: Xuesen Zhang, et al.
Published: (2023)

Regulatory utility of pharmacometrics in the development and evaluation of antimicrobial agents and its recent progress in China
by: Ming Zhao, et al.
Published: (2021)

Seeing the unseen of Chinese herbal medicine processing (Paozhi): advances in new perspectives
by: Xu Wu, et al.
Published: (2018)

Tacrolimus Loaded Cationic Liposomes for Dry Eye Treatment
by: Xiang Chen, et al.
Published: (2022)

Association between Statin Use and Survival in Cancer Patients with Brain Metastasis: Retrospective Analysis from the Chinese Population
by: Yu Min, et al.
Published: (2022)

Metabolomics of Clinical Poisoning by Aconitum Alkaloids Using Derivatization LC-MS
by: Yida Zhang, et al.
Published: (2019)

IGF2BP3 promotes glutamine metabolism of endometriosis by interacting with UCA1 to enhances the mRNA stability of GLS1
by: Honglin Wang, et al.
Published: (2024)

A Randomized, Open-Label, Phase I, Single-Dose Study of Antisense Oligonucleotide, Vupanorsen, in Chinese Adults with Elevated Triglycerides
by: Xiaojie Wu, et al.
Published: (2024)

Letrozole versus laparoscopic ovarian drilling in clomiphene citrate-resistant women with polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials
by: Qiong Yu, et al.
Published: (2019)

Age- and gender-specific trends in respiratory outpatient visits and diagnoses at a tertiary pediatric hospital in China: a 10-year retrospective study
by: Peng Shi, et al.
Published: (2020)

A Phase I Clinical Study Comparing the Tolerance, Immunogenicity, and Pharmacokinetics of Proposed Biosimilar BAT1806 and Reference Tocilizumab in Healthy Chinese Men
by: Hong Zhang, et al.
Published: (2021)

Time-related accurate investigation of multicomponent drug interventions in heart failure
by: Menglan Wang, et al.
Published: (2022)

Letrozole co-treatment in an antagonist protocol for overweight women undergoing IVF treatment: a retrospective study
by: Jing Lin, et al.
Published: (2024)

Association between Augmented Renal Clearance and Inadequate Vancomycin Pharmacokinetic/Pharmacodynamic Targets in Chinese Adult Patients: A Prospective Observational Study
by: Jinjin Zhao, et al.
Published: (2022)

The volatile oil from Acori Graminei Rhizoma downregulates NMDARs-ERK1/2-CREB signaling pathway to alleviate pain related emotions induced by inflammatory pain in rats
by: Shiqi LI, et al.
Published: (2023)

Investigating the Molecular Mechanism of Aqueous Extract of Cyclocarya paliurus on Ameliorating Diabetes by Transcriptome Profiling
by: Jing Li, et al.
Published: (2018)

The genetic variants at the HLA-DRB1 gene are associated with primary IgA nephropathy in Han Chinese
by: Jiyun Yang, et al.
Published: (2012)

Integrated Network Pharmacology and Comprehensive Bioinformatics Identifying the Mechanisms and Molecular Targets of Yizhiqingxin Formula for Treatment of Comorbidity With Alzheimer's Disease and Depression
by: Tingting Zhang, et al.
Published: (2022)

Legislation coverage for child injury prevention in China
by: Li Li, et al.
Published: (2015)

Integrating Transcriptome and Experiments Reveals the Anti-diabetic Mechanism of Cyclocarya paliurus Formula
by: Jing Li, et al.
Published: (2018)