Mitochondrial Fission Is Required for Angiotensin II-Induced Cardiomyocyte Apoptosis Mediated by a Sirt1-p53 Signaling Pathway

• Main Authors: Jia Qi (Author), Feng Wang (Author), Ping Yang (Author), Xuelian Wang (Author), Renjie Xu (Author), Jihui Chen (Author), Yanggang Yuan (Author), Zhaoyang Lu (Author), Junli Duan (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hypertension-induced cardiac apoptosis is a major contributor to early-stage heart-failure. Our previous studies have found that p53-mediated mitochondrial fission is involved in aldosterone-induced podocyte apoptosis. However, it is not clear that whether p53-induced mitochondrial fission is critic...