Enhanced Cardiac CaMKII Oxidation and CaMKII-Dependent SR Ca Leak in Patients with Sleep-Disordered Breathing

• Main Authors: Michael Arzt (Author), Marzena A. Drzymalski (Author), Sarah Ripfel (Author), Sebastian Meindl (Author), Alexander Biedermann (Author), Melanie Durczok (Author), Karoline Keller (Author), Julian Mustroph (Author), Sylvia Katz (Author), Maria Tafelmeier (Author), Simon Lebek (Author), Bernhard Flörchinger (Author), Daniele Camboni (Author), Sigrid Wittmann (Author), Johannes Backs (Author), Christof Schmid (Author), Lars S. Maier (Author), Stefan Wagner (Author)
• Format: Book
• Published: MDPI AG, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Sleep-disordered breathing (SDB) is associated with increased oxidant generation. Oxidized Ca/calmodulin kinase II (CaMKII) can contribute to atrial arrhythmias by the stimulation of sarcoplasmic reticulum Ca release events, i.e., Ca sparks. Methods: We prospectively enrolled 39 patients...