Salubrinal promotes phospho-eIF2α-dependent activation of UPR leading to autophagy-mediated attenuation of iron-induced insulin resistance

• Main Authors: Khang Nguyen (Author), Jialing Tang (Author), Sungji Cho (Author), Fan Ying (Author), Hye Kyoung Sung (Author), James Wonsuk Jahng (Author), Kostas Pantopoulos (Author), Gary Sweeney (Author)
• Format: Book
• Published: Elsevier, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Identification of new mechanisms mediating insulin sensitivity is important to allow validation of corresponding therapeutic targets. In this study, we first used a cellular model of skeletal muscle cell iron overload and found that endoplasmic reticulum (ER) stress and insulin resistance occurred a...