Pharmacological evidence of bradykinin regeneration from extended sequences that behave as peptidase-activated B2 receptor agonists

• Κύριοι συγγραφείς: Xavier eCharest-Morin (Συγγραφέας), Caroline eRoy (Συγγραφέας), Émile-Jacques eFortin (Συγγραφέας), Johanne eBouthillier (Συγγραφέας), François eMarceau (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Frontiers Media S.A., 2014-03-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

While bradykinin (BK) is known to be degraded by angiotensin converting enzyme (ACE), we have recently discovered that Met-Lys-BK-Ser-Ser is paradoxically activated by ACE. We designed and evaluated additional prodrug peptides extended around the BK sequence as potential ligands that could be locall...