Pharmacological evidence of bradykinin regeneration from extended sequences that behave as peptidase-activated B2 receptor agonists

• Main Authors: Xavier eCharest-Morin (Author), Caroline eRoy (Author), Émile-Jacques eFortin (Author), Johanne eBouthillier (Author), François eMarceau (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2014-03-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

While bradykinin (BK) is known to be degraded by angiotensin converting enzyme (ACE), we have recently discovered that Met-Lys-BK-Ser-Ser is paradoxically activated by ACE. We designed and evaluated additional prodrug peptides extended around the BK sequence as potential ligands that could be locall...