Targeting lung cancer with clinically relevant EGFR mutations using anti-EGFR RNA aptamer

• Main Authors: Brian J. Thomas (Author), Caitlyn Guldenpfennig (Author), Yue Guan (Author), Calvin Winkler (Author), Margaret Beecher (Author), Michaela Beedy (Author), Ashley F. Berendzen (Author), Lixin Ma (Author), Mark A. Daniels (Author), Donald H. Burke (Author), David Porciani (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A significant fraction of non-small cell lung cancer (NSCLC) cases are due to oncogenic mutations in the tyrosine kinase domain of the epidermal growth factor receptor (EGFR). Anti-EGFR antibodies have shown limited clinical benefit for NSCLC, whereas tyrosine kinase inhibitors (TKIs) are effective,...