Identification of Escherichia coli β-glucuronidase inhibitors from Polygonum cuspidatum Siebold & Zucc.

• Main Authors: Jing-Xin Li (Author), Yu Wang (Author), Ying Hao (Author), Xiao-Kui Huo (Author), Cheng-Peng Sun (Author), Xiao-Xia Zhao (Author), Jin-Cheng Wang (Author), Jian-Bin Zhang (Author), Jing Ning (Author), Xiang-Ge Tian (Author), Chao Wang (Author), Wen-Yu Zhao (Author), Xia Lv (Author), Ya-Chen Li (Author), Xiao-Chi Ma (Author)
• Format: Book
• Published: Universidade de São Paulo, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Gut bacterial β-glucuronidase (GUS) can reactivate xenobiotics that exert enterohepatic circulation- triggered gastrointestinal tract toxicity. GUS inhibitors can alleviate drug-induced enteropathy and improve treatment outcomes. We evaluated the inhibitory effect of Polygonum cuspidatum Si...