Identification of Structural Features for the Inhibition of OAT3-Mediated Uptake of Enalaprilat by Selected Drugs and Flavonoids

• Váldodahkkit: Yao Ni (Dahkki), Zelin Duan (Dahkki), Dandan Zhou (Dahkki), Shuai Liu (Dahkki), Huida Wan (Dahkki), Chunshan Gui (Dahkki), Hongjian Zhang (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Frontiers Media S.A., 2020-05-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Enalaprilat is the active metabolite of enalapril, a widely used antihypertension drug. The human organic anion transporter 3 (OAT3), which is highly expressed in the kidney, plays a critical role in the renal clearance of many drugs. While urinary excretion is the primary elimination route of enala...