Identification of Structural Features for the Inhibition of OAT3-Mediated Uptake of Enalaprilat by Selected Drugs and Flavonoids

Enalaprilat is the active metabolite of enalapril, a widely used antihypertension drug. The human organic anion transporter 3 (OAT3), which is highly expressed in the kidney, plays a critical role in the renal clearance of many drugs. While urinary excretion is the primary elimination route of enala...

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Main Authors: Yao Ni (Author), Zelin Duan (Author), Dandan Zhou (Author), Shuai Liu (Author), Huida Wan (Author), Chunshan Gui (Author), Hongjian Zhang (Author)
Format: Book
Published: Frontiers Media S.A., 2020-05-01T00:00:00Z.
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