Utilization of Human Liver Microsomes to Explain Individual Differences in Paclitaxel Metabolism by CYP2C8 and CYP3A4

• Main Authors: Ryoko Taniguchi (Author), Toshio Kumai (Author), Naoki Matsumoto (Author), Minoru Watanabe (Author), Koji Kamio (Author), Satoshi Suzuki (Author), Shinichi Kobayashi (Author)
• Format: Book
• Published: Elsevier, 2005-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Paclitaxel is widely used for treatment of malignant tumors. Paclitaxel is metabolized by CYP2C8 and CYP3A4, and these enzymes are known to differ between individuals, although the details have not been clarified. Recent progress in pharmacogenetics has shown that genetic polymorphisms of metabolic...