Role of Hepatocyte Transporters in Drug-Induced Liver Injury (DILI)-In Vitro Testing
Bile acids and bile salts (BA/BS) are substrates of both influx and efflux transporters on hepatocytes. Canalicular efflux transporters, such as BSEP and MRP2, are crucial for the removal of BA/BS to the bile. Basolateral influx transporters, such as NTCP, OATP1B1/1B3, and OSTα/β, cooperate with can...
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2022-12-01T00:00:00Z.
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