Identification of a dual TAOK1 and MAP4K5 inhibitor using a structure-based virtual screening approach

• Main Authors: Min-Wu Chao (Author), Tony Eight Lin (Author), Wei-Chun HuangFu (Author), Chao-Di Chang (Author), Huang-Ju Tu (Author), Liang-Chieh Chen (Author), Shih-Chung Yen (Author), Tzu-Ying Sung (Author), Wei-Jan Huang (Author), Chia-Ron Yang (Author), Shiow-Lin Pan (Author), Kai-Cheng Hsu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The STE20 kinase family is a complex signalling cascade that regulates cytoskeletal organisation and modulates the stress response. This signalling cascade includes various kinase mediators, such as TAOK1 and MAP4K5. The dysregulation of the STE20 kinase pathway is linked with cancer malignancy. A s...