Simultaneous Determination of A Novel Antitrypanosomal Compound (OSU-36) and its Ester Derivative (OSU-40) in Plasma by HPLC: Application to First Pharmacokinetic Study in Rats

• Main Authors: Pavel Gershkovich (Author), Kishor M. Wasan (Author), Olena Sivak (Author), Summer Lysakowski (Author), Carolyn Reid (Author), Kokku Premalatha (Author), Karl A. Werbovetz (Author)
• Format: Book
• Published: Frontiers Media S.A., 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose. To develop an HPLC-UV method for determination of a novel antitrypanosomal compound (OSU-36) and its ester prodrug (OSU-40) in rat plasma and to apply the method for pharmacokinetic evaluation of both compounds in rats. Methods. Since an attempt to assay for OSU-36 and OSU-40 in non-stabili...