On-Chip Synthesis of Hyaluronic Acid-Based Nanoparticles for Selective Inhibition of CD44+ Human Mesenchymal Stem Cell Proliferation

• Main Authors: Enrica Chiesa (Author), Federica Riva (Author), Rossella Dorati (Author), Antonietta Greco (Author), Stefania Ricci (Author), Silvia Pisani (Author), Maddalena Patrini (Author), Tiziana Modena (Author), Bice Conti (Author), Ida Genta (Author)
• Format: Book
• Published: MDPI AG, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, an innovative microfluidics-based method was developed for one-step synthesis of hyaluronic acid (HA)-based nanoparticles (NPs), by exploiting polyelectrolytic interactions between HA and chitosan (CS), in order to improve reliability, reproducibility and possible scale-up of the NPs...