Structure-Activity Relationship of Synthetic Linear KTS-Peptides Containing Meta-Aminobenzoic Acid as Antagonists of α1β1 Integrin with Anti-Angiogenic and Melanoma Anti-Tumor Activities

• मुख्य लेखकों: Majdi Saleem Naamneh (लेखक), Tatjana Momic (लेखक), Michal Klazas (लेखक), Julius Grosche (लेखक), Johannes A. Eble (लेखक), Cezary Marcinkiewicz (लेखक), Netaly Khazanov (लेखक), Hanoch Senderowitz (लेखक), Amnon Hoffman (लेखक), Chaim Gilon (लेखक), Jehoshua Katzhendler (लेखक), Philip Lazarovici (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2024-04-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

To develop peptide drugs targeting integrin receptors, synthetic peptide ligands endowed with well-defined selective binding motifs are necessary. The snake venom KTS-containing disintegrins, which selectively block collagen α1β1 integrin, were used as lead compounds for the synthesis and structure-...