Structure-Activity Relationship of Synthetic Linear KTS-Peptides Containing Meta-Aminobenzoic Acid as Antagonists of α1β1 Integrin with Anti-Angiogenic and Melanoma Anti-Tumor Activities

Structure-Activity Relationship of Synthetic Linear KTS-Peptides Containing Meta-Aminobenzoic Acid as Antagonists of α1β1 Integrin with Anti-Angiogenic and Melanoma Anti-Tumor Activities

To develop peptide drugs targeting integrin receptors, synthetic peptide ligands endowed with well-defined selective binding motifs are necessary. The snake venom KTS-containing disintegrins, which selectively block collagen α1β1 integrin, were used as lead compounds for the synthesis and structure-...

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Main Authors: Majdi Saleem Naamneh (Author), Tatjana Momic (Author), Michal Klazas (Author), Julius Grosche (Author), Johannes A. Eble (Author), Cezary Marcinkiewicz (Author), Netaly Khazanov (Author), Hanoch Senderowitz (Author), Amnon Hoffman (Author), Chaim Gilon (Author), Jehoshua Katzhendler (Author), Philip Lazarovici (Author)
Format: Book
Published: MDPI AG, 2024-04-01T00:00:00Z.
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