The human inactive X chromosome modulates expression of the active X chromosome

• Main Authors: Adrianna K. San Roman (Author), Alexander K. Godfrey (Author), Helen Skaletsky (Author), Daniel W. Bellott (Author), Abigail F. Groff (Author), Hannah L. Harris (Author), Laura V. Blanton (Author), Jennifer F. Hughes (Author), Laura Brown (Author), Sidaly Phou (Author), Ashley Buscetta (Author), Paul Kruszka (Author), Nicole Banks (Author), Amalia Dutra (Author), Evgenia Pak (Author), Patricia C. Lasutschinkow (Author), Colleen Keen (Author), Shanlee M. Davis (Author), Nicole R. Tartaglia (Author), Carole Samango-Sprouse (Author), Maximilian Muenke (Author), David C. Page (Author)
• Format: Book
• Published: Elsevier, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary: The "inactive" X chromosome (Xi) has been assumed to have little impact, in trans, on the "active" X (Xa). To test this, we quantified Xi and Xa gene expression in individuals with one Xa and zero to three Xis. Our linear modeling revealed modular Xi and Xa transcriptome...