Alteration of EIF2 Signaling, Glycolysis, and Dopamine Secretion in Form-Deprived Myopia in Response to 1% Atropine Treatment: Evidence From Interactive iTRAQ-MS and SWATH-MS Proteomics Using a Guinea Pig Model

• Main Authors: Ying Zhu (Author), Jing Fang Bian (Author), Da Qian Lu (Author), Chi Ho To (Author), Carly Siu-Yin Lam (Author), King Kit Li (Author), Feng Juan Yu (Author), Bo Teng Gong (Author), Qiong Wang (Author), Xiao Wen Ji (Author), Hong Mei Zhang (Author), Hong Nian (Author), Thomas Chuen Lam (Author), Rui Hua Wei (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: Atropine, a non-selective muscarinic antagonist, effectively slows down myopia progression in human adolescents and several animal models. However, the underlying molecular mechanism is unclear. The current study investigated retinal protein changes of form-deprived myopic (FDM) guinea pigs...