Differential Effects of Polyphenols on Insulin Proteolysis by the Insulin-Degrading Enzyme

• Main Authors: Qiuchen Zheng (Author), Micheal T. Kebede (Author), Bethany Lee (Author), Claire A. Krasinski (Author), Saadman Islam (Author), Liliana A. Wurfl (Author), Merc M. Kemeh (Author), Valerie A. Ivancic (Author), Charles E. Jakobsche (Author), Donald E. Spratt (Author), Noel D. Lazo (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The insulin-degrading enzyme (IDE) possesses a strong ability to degrade insulin and Aβ42 that has been linked to the neurodegeneration in Alzheimer's disease (AD). Given this, an attractive IDE-centric strategy for the development of therapeutics for AD is to boost IDE's activity for the...