Targeted SHP-1 Silencing Modulates the Macrophage Phenotype, Leading to Metabolic Improvement in Dietary Obese Mice

• Κύριοι συγγραφείς: Yadhu Sharma (Συγγραφέας), Altaf Ahmad (Συγγραφέας), Prabhu Srinivas Yavvari (Συγγραφέας), Sandeep Kumar Muwal (Συγγραφέας), Avinash Bajaj (Συγγραφέας), Farah Khan (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Elsevier, 2019-06-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Chronic over-nutrition promotes adipocyte hypertrophy that creates inflammatory milieu leading to macrophage infiltration and their phenotypic switching during obesity. The SH2 domain-containing protein tyrosine phosphatase 1 (SHP-1) has been identified as an important player in inflammatory disease...