Limiting extracellular matrix expansion in diet-induced obese mice reduces cardiac insulin resistance and prevents myocardial remodelling

• Main Authors: Vishal Musale (Author), Colin E. Murdoch (Author), Ayman K. Banah (Author), Annie Hasib (Author), Chandani K. Hennayake (Author), Bo Dong (Author), Chim C. Lang (Author), David H. Wasserman (Author), Li Kang (Author)
• Format: Book
• Published: Elsevier, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Obesity increases deposition of extracellular matrix (ECM) components of cardiac tissue. Since obesity aggregates with insulin resistance and heart disease, it is imperative to determine whether the increased ECM deposition contributes to this disease cluster. The hypotheses tested in thi...