Complex formation of anti‐VEGF‐C with VEGF‐C released during blood coagulation resulted in an artifact in its serum pharmacokinetics

• Main Authors: Daniela Bumbaca Yadav (Author), Arthur E. Reyes II (Author), Priyanka Gupta (Author), Jean‐Michel Vernes (Author), Y. Gloria Meng (Author), Michelle G. Schweiger (Author), Shannon L. Stainton (Author), Germaine Fuh (Author), Paul J. Fielder (Author), Amrita V. Kamath (Author), Ben‐Quan Shen (Author)
• Format: Book
• Published: Wiley, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract A phage‐derived human monoclonal antibody against VEGF‐C was developed as a potential anti‐tumor therapeutic and exhibited fast clearance in preclinical species, with notably faster clearance in serum than in plasma. The purpose of this work was to understand the factors contributing to its...