Complex formation of anti‐VEGF‐C with VEGF‐C released during blood coagulation resulted in an artifact in its serum pharmacokinetics

• मुख्य लेखकों: Daniela Bumbaca Yadav (लेखक), Arthur E. Reyes II (लेखक), Priyanka Gupta (लेखक), Jean‐Michel Vernes (लेखक), Y. Gloria Meng (लेखक), Michelle G. Schweiger (लेखक), Shannon L. Stainton (लेखक), Germaine Fuh (लेखक), Paul J. Fielder (लेखक), Amrita V. Kamath (लेखक), Ben‐Quan Shen (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Wiley, 2020-04-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract A phage‐derived human monoclonal antibody against VEGF‐C was developed as a potential anti‐tumor therapeutic and exhibited fast clearance in preclinical species, with notably faster clearance in serum than in plasma. The purpose of this work was to understand the factors contributing to its...