Anti-colon cancer activity of amino acid ester betulinates: Apoptosis induction and IL1B gene expression in PBMCs by the lead compound

• Main Authors: Lyuba Miteva (Author), Antonia Grigorova (Author), Neli Dimitrova (Author), Boncho Grigorov (Author), Ani Georgieva (Author), Paula Ossowicz-Rupniewska (Author), Joanna Klebeko (Author), Maya Guncheva (Author)
• Format: Book
• Published: Pensoft Publishers, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Betulinic acid (BA) is a natural pentacyclic triterpenoid with significant pharmaceutical potential. We found that converting BA into amino acid ethyl ester salts alters its cytotoxic effect on colorectal adenocarcinoma cells (HT-29). Among these salts, the estimated half-maximal inhibitory concentr...