Gene expression patterns of dengue virus-infected children from nicaragua reveal a distinct signature of increased metabolism.

• Main Authors: P'ng Loke (Author), Samantha N Hammond (Author), Jacqueline M Leung (Author), Charles C Kim (Author), Sajeev Batra (Author), Crisanta Rocha (Author), Angel Balmaseda (Author), Eva Harris (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Infection with dengue viruses (DENV) leads to a spectrum of disease outcomes. The pathophysiology of severe versus non-severe manifestations of DENV infection may be driven by host responses, which could be reflected in the transcriptional profiles of peripheral blood immune cells.We conducted genom...