JNK and NADPH Oxidase Involved in Fluoride-Induced Oxidative Stress in BV-2 Microglia Cells

• Main Authors: Ling Yan (Author), Shengnan Liu (Author), Chen Wang (Author), Fei Wang (Author), Yingli Song (Author), Nan Yan (Author), Shuhua Xi (Author), Ziyou Liu (Author), Guifan Sun (Author)
• Format: Book
• Published: Hindawi Limited, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Excessive fluoride may cause central nervous system (CNS) dysfunction, and oxidative stress is a recognized mode of action of fluoride toxicity. In CNS, activated microglial cells can release more reactive oxygen species (ROS), and NADPH oxidase (NOX) is the major enzyme for the production of extrac...