The Topical Nanodelivery of Vismodegib Enhances Its Skin Penetration and Performance <i>In Vitro</i> While Reducing Its Toxicity <i>In Vivo</i>

The Topical Nanodelivery of Vismodegib Enhances Its Skin Penetration and Performance <i>In Vitro</i> While Reducing Its Toxicity <i>In Vivo</i>

Vismodegib is a first-in-class inhibitor for advanced basal cell carcinoma treatment. Its daily oral doses present a high distribution volume and several side effects. We evaluated its skin penetration loaded in diverse nanosystems as potential strategies to reduce side effects and drug quantities....

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Main Authors: Maria Natalia Calienni (Author), Daniela Maza Vega (Author), C. Facundo Temprana (Author), María Cecilia Izquierdo (Author), David E. Ybarra (Author), Ezequiel Bernabeu (Author), Marcela Moretton (Author), Fernando C. Alvira (Author), Diego Chiappetta (Author), Silvia del Valle Alonso (Author), María Jimena Prieto (Author), Jorge Montanari (Author)
Format: Book
Published: MDPI AG, 2021-02-01T00:00:00Z.
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3rd Floor Main Library

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