Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells

• Main Authors: Maria Kopsida (Author), Ada Lerma Clavero (Author), Jaafar Khaled (Author), David Balgoma (Author), Clara Luna-Marco (Author), Azazul Chowdhury (Author), Sofi Sennefelt Nyman (Author), Fredrik Rorsman (Author), Charlotte Ebeling Barbier (Author), Peter Bergsten (Author), Hans Lennernäs (Author), Mikael Hedeland (Author), Femke Heindryckx (Author)
• Format: Book
• Published: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hepatocellular carcinoma (HCC) is characterized by a low and variable response to chemotherapeutic treatments. One contributing factor to the overall pharmacodynamics is the activation of endoplasmic reticulum (ER) stress pathways. This is a cellular stress mechanism that becomes activated when the...