Switching obese mothers to a healthy diet improves fetal hypoxemia, hepatic metabolites, and lipotoxicity in non-human primates

• Main Authors: Stephanie R. Wesolowski (Author), Christopher M. Mulligan (Author), Rachel C. Janssen (Author), Peter R. Baker, II (Author), Bryan C. Bergman (Author), Angelo D'Alessandro (Author), Travis Nemkov (Author), Kenneth N. Maclean (Author), Hua Jiang (Author), Tyler A. Dean (Author), Diana L. Takahashi (Author), Paul Kievit (Author), Carrie E. McCurdy (Author), Kjersti M. Aagaard (Author), Jacob E. Friedman (Author)
• Format: Book
• Published: Elsevier, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Non-alcoholic fatty liver disease (NAFLD) risk begins in utero in offspring of obese mothers. A critical unmet need in this field is to understand the pathways and biomarkers underlying fetal hepatic lipotoxicity and whether maternal dietary intervention during pregnancy is an effective c...