Recessive, gain-of-function toxicity in an APOL1 BAC transgenic mouse model mirrors human APOL1 kidney disease

• Main Authors: Gizelle M. McCarthy (Author), Angelo Blasio (Author), Olivia G. Donovan (Author), Lena B. Schaller (Author), Althea Bock-Hughes (Author), Jose M. Magraner (Author), Jung Hee Suh (Author), Calum F. Tattersfield (Author), Isaac E. Stillman (Author), Shrijal S. Shah (Author), Zsuzsanna K. Zsengeller (Author), Balajikarthick Subramanian (Author), David J. Friedman (Author), Martin R. Pollak (Author)
• Format: Book
• Published: The Company of Biologists, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

People of recent sub-Saharan African ancestry develop kidney failure much more frequently than other groups. A large fraction of this disparity is due to two coding sequence variants in the APOL1 gene. Inheriting two copies of these APOL1 risk variants, known as G1 and G2, causes high rates of focal...