Methylglyoxal-Induced Dysfunction in Brain Endothelial Cells via the Suppression of Akt/HIF-1α Pathway and Activation of Mitophagy Associated with Increased Reactive Oxygen Species

• Main Authors: Donghyun Kim (Author), Kyeong-A Kim (Author), Jeong-Hyeon Kim (Author), Eun-Hye Kim (Author), Ok-Nam Bae (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2020-09-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Methylglyoxal (MG) is a dicarbonyl compound, the level of which is increased in the blood of diabetes patients. MG is reported to be involved in the development of cerebrovascular complications in diabetes, but the exact mechanisms need to be elucidated. Here, we investigated the possible roles of o...