Dissolution of theophylline from extended-release tablets under cyclic retrograde peristaltic contractions in the Dynamic Colon Model

• Egile Nagusiak: Connor O'Farrell (Egilea), Konstantinos Stamatopoulos (Egilea), Mark J. H. Simmons (Egilea), Hannah Batchelor (Egilea)
• Formatua: Liburua
• Argitaratua: University of Huddersfield Press, 2022-11-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

The dynamic colon model isa biorelevant in vitro model of the human proximal colon. In vivo, the large intestine mixes its contents using peristaltic waves that propagate both forwards(antegrade) and backwards (retrograde). This work studies the dissolution profile of theophylline from Uniphyllin Co...