Free fatty acid receptor 1 stimulates cAMP production and gut hormone secretion through Gq-mediated activation of adenylate cyclase 2

• Main Authors: Jacob Emil Petersen (Author), Maria Hauge Pedersen (Author), Oksana Dmytriyeva (Author), Emilie Nellemose (Author), Tulika Arora (Author), Maja Storm Engelstoft (Author), Wesley B. Asher (Author), Jonathan A. Javitch (Author), Thue W. Schwartz (Author), Mette Trauelsen (Author)
• Format: Book
• Published: Elsevier, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Free fatty acid receptor 1 (FFAR1) is highly expressed in enteroendocrine cells of the small intestine and pancreatic beta cells, where FFAR1 agonists function as GLP-1 and insulin secretagogues, respectively. Most efficacious are so-called second-generation synthetic agonists such as AM5...