A Fixed-Dose Combination, QXOH/Levobupivacaine, Produces Long-Acting Local Anesthesia in Rats Without Additional Toxicity

• Main Authors: Qinqin Yin (Author), Yujun Zhang (Author), Rong Lv (Author), Deying Gong (Author), Bowen Ke (Author), Jun Yang (Author), Lei Tang (Author), Wensheng Zhang (Author), Tao Zhu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

QXOH, a QX314 derivative with longer duration and lesser local toxicity, is a novel local anesthetic in preclinical drug development. Previous studies demonstrated that bupivacaine can prolong the effects of QX314. So, we attempted to combine QXOH with levobupivacaine to shorten the onset time and l...