Prioritized polycystic kidney disease drug targets and repurposing candidates from pre-cystic and cystic mouse Pkd2 model gene expression reversion

Prioritized polycystic kidney disease drug targets and repurposing candidates from pre-cystic and cystic mouse Pkd2 model gene expression reversion

Abstract Background Autosomal dominant polycystic kidney disease (ADPKD) is one of the most prevalent monogenic human diseases. It is mostly caused by pathogenic variants in PKD1 or PKD2 genes that encode interacting transmembrane proteins polycystin-1 (PC1) and polycystin-2 (PC2). Among many pathog...

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Main Authors: Elizabeth J. Wilk (Author), Timothy C. Howton (Author), Jennifer L. Fisher (Author), Vishal H. Oza (Author), Ryan T. Brownlee (Author), Kasi C. McPherson (Author), Hannah L. Cleary (Author), Bradley K. Yoder (Author), James F. George (Author), Michal Mrug (Author), Brittany N. Lasseigne (Author)
Format: Book
Published: BMC, 2023-05-01T00:00:00Z.
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