Efficacy and safety of FLT3 inhibitors in monotherapy of hematological and solid malignancies: a systemic analysis of clinical trials

• Main Authors: Yuying Zhao (Author), Xuedi Zhang (Author), Xiaoyan Ding (Author), Ying Wang (Author), Zhenpeng Li (Author), Ronglan Zhao (Author), Hai-En Cheng (Author), Yanli Sun (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: FLT3 mutations are closely associated with the occurrence of hematological and solid malignancies, especially with acute myeloid leukemia. Currently, several FLT3 inhibitors are in clinical trials, and some have been applied in clinic. However, the safety, efficacy and pharmacodynamics...