An in-silico approach towards multivariate acceptable ranges in biopharmaceutical manufacturing

• Main Authors: Marco Kunzelmann (Author), Judith Thoma (Author), Sabrina Laibacher (Author), Joey M. Studts (Author), Beate Presser (Author), Julia Spitz (Author)
• Format: Book
• Published: SpringerOpen, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Multivariate interactions between process parameters can heavily impact product quality and process performance in biopharmaceutical manufacturing processes. Thus, multivariate interactions should be identified and appropriately controlled. This article describes an in-silico approach to es...