Mechanism of action of hypoglycemic effects of an intestine-specific inhibitor of microsomal triglyceride transfer protein (MTP) in obese rats

• Main Authors: Shohei Sakata (Author), Sohei Katsumi (Author), Yasuko Mera (Author), Yukiharu Kuroki (Author), Reiko Nashida (Author), Makoto Kakutani (Author), Takeshi Ohta (Author)
• Format: Book
• Published: Elsevier, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Diminished insulin sensitivity in the peripheral tissues and failure of pancreatic beta cells to secrete insulin are known major determinants of type 2 diabetes mellitus. JTT-130, an intestine-specific microsomal transfer protein inhibitor, has been shown to suppress high fat-induced obesity and ame...