Osteopontin Augments M2 Microglia Response and Separates M1- and M2-Polarized Microglial Activation in Permanent Focal Cerebral Ischemia

• Main Authors: Anne Ladwig (Author), Helene Luise Walter (Author), Jörg Hucklenbroich (Author), Antje Willuweit (Author), Karl-Josef Langen (Author), Gereon Rudolph Fink (Author), Maria Adele Rueger (Author), Michael Schroeter (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. Focal cerebral ischemia induces distinct neuroinflammatory processes. We recently reported the extracellular phosphor-glyco-protein osteopontin (OPN) to directly affect primary microglia in vitro, promoting survival while shifting their inflammatory profile towards a more neutral phenoty...