Trimebutine, a small molecule mimetic agonist of adhesion molecule L1, contributes to functional recovery after spinal cord injury in mice

• Main Authors: Junping Xu (Author), Chengliang Hu (Author), Qiong Jiang (Author), Hongchao Pan (Author), Huifan Shen (Author), Melitta Schachner (Author)
• Format: Book
• Published: The Company of Biologists, 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Curing spinal cord injury (SCI) in mammals is a daunting task because of the lack of permissive mechanisms and strong inhibitory responses at and around the lesion. The neural cell adhesion molecule L1CAM (L1) has been shown to favor axonal regrowth and enhance neuronal survival and synaptic plastic...