In vitro metabolic characterization of the SARS-CoV-2 papain-like protease inhibitors GRL0617 and HY-17542

• Những tác giả chính: Hyunki Cho (Tác giả), Young Jun Kim (Tác giả), Jung-Woo Chae (Tác giả), Markus R. Meyer (Tác giả), Sang Kyum Kim (Tác giả), Chang Seon Ryu (Tác giả)
• Định dạng: Sách
• Được phát hành: Frontiers Media S.A., 2023-02-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

The SARS-CoV-2 pandemic requires a new therapeutic target for viral infection, and papain-like protease (Plpro) has been suggested as a druggable target. This in-vitro study was conducted to examine the drug metabolism of the GRL0617 and HY-17542, Plpro inhibitors. Metabolism of these inhibitors was...