Shikonin reduces M2 macrophage population in ovarian cancer by repressing exosome production and the exosomal galectin 3-mediated β-catenin activation

• Egile Nagusiak: Min Wang (Egilea), Yangyan Sun (Egilea), Rui Gu (Egilea), Yan Tang (Egilea), Guorong Han (Egilea), Shaojie Zhao (Egilea)
• Formatua: Liburua
• Argitaratua: BMC, 2024-05-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Abstract Background Shikonin (SK), a naphthoquinone with anti-tumor effects, has been found to decrease production of tumor-associated exosomes (exo). This study aims to verify the treatment effect of SK on ovarian cancer (OC) cells, especially on the production of exo and their subsequent effect on...