Preparation, Characterization and Pharmacokinetics of Tolfenamic Acid-Loaded Solid Lipid Nanoparticles

• Main Authors: Wei Xu (Author), Zhaoyou Deng (Author), Yifei Xiang (Author), Dujuan Zhu (Author), Dandan Yi (Author), Yihao Mo (Author), Yu Liu (Author), Lanqian Qin (Author), Ling Huang (Author), Bingjie Wan (Author), Liqin Wu (Author), Xin Feng (Author), Jiakang He (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The clinical use of nonsteroidal anti-inflammatory drugs is limited by their poor water solubility, unstable absorption, and low bioavailability. Solid lipid nanoparticles (SLNs) exhibit high biocompatibility and the ability to improve the bioavailability of drugs with low water solubility. Therefor...