Development of a Model-Informed Dosing Tool to Optimise Initial Antibiotic Dosing-A Translational Example for Intensive Care Units

• Main Authors: Ferdinand Anton Weinelt (Author), Miriam Songa Stegemann (Author), Anja Theloe (Author), Frieder Pfäfflin (Author), Stephan Achterberg (Author), Lisa Schmitt (Author), Wilhelm Huisinga (Author), Robin Michelet (Author), Stefanie Hennig (Author), Charlotte Kloft (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The prevalence and mortality rates of severe infections are high in intensive care units (ICUs). At the same time, the high pharmacokinetic variability observed in ICU patients increases the risk of inadequate antibiotic drug exposure. Therefore, dosing tailored to specific patient characteristics h...