Activated Protein C Inhibits Proliferation and Tumor Necrosis Factor α-Stimulated Activation of p38, c-Jun NH2-Terminal Kinase (JNK) and Akt in Rheumatoid Synovial Fibroblasts

• 主要な著者: Sohel M. Julovi (著者), Kaitlin Shen (著者), Kelly McKelvey (著者), Nikita Minhas (著者), Lyn March (著者), Christopher J. Jackson (著者)
• フォーマット: 図書
• 出版事項: BMC, 2013-09-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Abstract Synovial fibroblast proliferation Is a hallmark of the Invasive pannus in the rheumatoid joint. Activated protein C (APC) is a natural anticoagulant that exerts antiinflammatory and cyto-protective effects in various diseases via endothelial protein C receptor (EPCR) and proteinase-activate...