Pharmacokinetic modeling of R and S‐Methadone and their metabolites to study the effects of various covariates in post‐operative children

• Main Authors: Blessed W. Aruldhas (Author), Sara K. Quinney (Author), Brian R. Overholser (Author), Michael A. Heathman (Author), Andrea R. Masters (Author), Reynold C. Ly (Author), Hongyu Gao (Author), Senthil Packiasabapathy (Author), Senthilkumar Sadhasivam (Author)
• Format: Book
• Published: Wiley, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Methadone is a synthetic opioid used as an analgesic and for the treatment of opioid abuse disorder. The analgesic dose in the pediatric population is not well‐defined. The pharmacokinetics (PKs) of methadone is highly variable due to the variability in alpha‐1 acid glycoprotein (AAG) and g...