LncRNA AC006064.4-201 serves as a novel molecular marker in alleviating cartilage senescence and protecting against osteoarthritis by destabilizing CDKN1B mRNA via interacting with PTBP1

• Main Authors: Panyang Shen (Author), Jun Gao (Author), Shaohan Huang (Author), Chenan You (Author), Haitao Wang (Author), Pengyu Chen (Author), Teng Yao (Author), Tianyou Gao (Author), Bohao Zhou (Author), Shuying Shen (Author), Xing Zhao (Author), Jianjun Ma (Author)
• Format: Book
• Published: BMC, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Osteoarthritis (OA) is the most prevalent age-related disease in the world. Chondrocytes undergo an age-dependent decline in their proliferation and synthetic capacity, which is the main cause of OA development. However, the intrinsic mechanism of chondrocyte senescence is still...