Old drug, new indication: Olsalazine sodium reduced serum uric acid levels in mice via inhibiting xanthine oxidoreductase activity

• Main Authors: Yanfen Niu (Author), Hongjian Li (Author), Lihui Gao (Author), Hua Lin (Author), Hsiangfu Kung (Author), Marie Chia-mi Lin (Author), Kwong-Sak Leung (Author), Man-Hon Wong (Author), Wenyong Xiong (Author), Ling Li (Author)
• Format: Book
• Published: Elsevier, 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hyperuricemia, a long-term purine metabolic disorder, is a well-known risk factor for gout, hypertension and diabetes. In maintaining normal whole-body purine levels, xanthine oxidase (XOD) is a key enzyme in the purine metabolic pathway, as it catalyzes the oxidation of hypoxanthine to xanthine and...